Chemoprotective Effect of Leaf Extracts of Cecropia distachya Huber (Urticaceae) in Mice Submitted to Oxidative Stress Induced by Cyclophosphamide
DOI:
https://doi.org/10.21664/2238-8869.2020v9i2.p103-127Palavras-chave:
Histologia, lesões oxidativas, hipoglicemia, imunossupressãoResumo
The objective of this work was to evaluate the chemoprotective effects of the embaúba Cecropia distachya Huber (two methanolic fractions: F1 and F2) on oxidative stress induced by cyclophosphamide (75 mg kg-1) in mice, as well as phytochemical analyzes by LC-MS/MS. In the experimental model, the fractions increased the hepatic and cardiac catalase (CAT), reduced glutathione (GSH) of the kidney and the heart. F1 increased platelet levels (PLT), hemogram (RBC), hematocrit (HCT) and hemoglobin (Hb) and F1 reduced hepatic lipid peroxidation (TBARS) and aspartate aminotransferase (AST) activity increased. F1 was attributed to possible hypoglycemic activity and possible immunosuppressive effects and F2 presented antimutagenic activity. In some cases, the fractions were also hepatotoxic. These results demonstrated that the fractions stimulate the antioxidant defenses, being hypoglycemic (F1) and antimutagenic (F2), and, the harmful effects attributed to the fractions may be the association of compounds that were not elucidated in this work.
Referências
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Iriti M, Kubina R, Cochis A, Sorrentino R, Varoni EM, Kabała-Dzik A, Azzimonti B, Dziedzic A, Rimondini L, Wojtyczka RD 2017. Rutin, a quercetin glycoside, restores chemosensitivity in human breast cancer cells. Phytother. Res. 31, 1529-1538.
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Müller SD, Florentino D, Ortmann CF, Martins FA, Danielski LG, Michels M, Constantino, LS, Petronilho F, Reginatto, FH 2016. Anti-inflammatory and antioxidant activities of aqueous extract of Cecropia glaziovii leaves. J. Ethnopharmacol. 185, 255–262.
Nafees S, Rashid S, Ali N, Hasan SK, Sultana S 2015. Rutin ameliorates cyclophosphamide induced oxidative stress and inflammation in Wistar rats: Role of NFjB/MAPK pathway. Chem. Biol. Interact. 231, 98–107.
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2020-08-31
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LUIZ, Tatiane Cordeiro; RIALTO, Luiz Henrique; DE MOURA, Fernando Rafael; AGUIAR, Danilo Henrique; SUGUI, Marina Mariko; BICUDO, Rogério de Campos; SINHORIN, Adilson Paulo; SINHORIN, Valéria Dornelles Gindri. Chemoprotective Effect of Leaf Extracts of Cecropia distachya Huber (Urticaceae) in Mice Submitted to Oxidative Stress Induced by Cyclophosphamide. Fronteira: Journal of Social, Technological and Environmental Science, [S. l.], v. 9, n. 2, p. 103–127, 2020. DOI: 10.21664/2238-8869.2020v9i2.p103-127. Disponível em: https://periodicos.unievangelica.edu.br/index.php/fronteiras/article/view/3022. Acesso em: 24 nov. 2024.
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