KETAMINE IN ACUTE PHARMACOLOGICAL MANAGEMENT OF SUICIDAL IDEATION
DOI:
https://doi.org/10.29237/2358-9868.2019v7i1.p131-141Keywords:
Suicide, Suicidal Ideation, KetamineAbstract
ABSTRACT
Objective: Suicide ideation is the most often psychiatric emergency found in the emergency context. However, because of the complex interaction between their risk factors, patient discomfort in addressing the issue, clinical individuality of episodes and deficits in pharmacological interventions, there are few protocols that provide algorithms for the management of the entity. Although the efficacy of Ketamine in the management of depression has recently been demonstrated, little is known about its efficacy in managing suicidal ideation. In this review, were evaluated clinical trials that discussed the use of ketamine in the acute treatment of suicidal ideation associated or not with depressive disorders, in order to determine if the use of the drug is safe and effective in the management of this psychiatric emergency. Data sources: Searches were performed in PubMed, SciELO, Web of Science, Bireme and Scopus databases with the MeSH terms "Ketamine" and "Suicide ideation". Data synthesis: After selection of randomized clinical trials and exclusion of duplicates, 10 studies were included in this review. Conclusions: Studies have shown that ketamine is a fast-acting drug and possibly sustained in suicidal ideation, as well as mild and self-limiting adverse effects. However, such results should be replicated in a larger number of patients, especially regarding the use of maintenance doses.
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