Aspectos fisiopatológicos relacionados ao eixo microbiota-intestino-cérebro

  • Isabelle Helena Lobão Bentes Souza Centro Universitário de Anápolis - UniEVANGÉLICA
  • Letícia de Souza Galvão Centro Universitário de Anápolis - UniEVANGÉLICA
  • Radmila Ferreira Monteiro Centro Universitário de Anápolis - UniEVANGÉLICA
  • Raphael Helvécio Carvalho de Oliveira Diniz Centro Universitário de Anápolis - UniEVANGÉLICA
  • Vitória Maritzzi Costa Mendonça Centro Universitário de Anápolis - UniEVANGÉLICA
  • Rodrigo Scaliante de Moura Centro Universitário de Anápolis - UniEVANGÉLICA

Resumo

A microbiota intestinal é reconhecida por executar funções na saúde do hospedeiro de forma clara no trato gastrointestinal através da simbiose. Recentemente, a elucidação de sua relação com o sistema nervoso central demonstrou a influência do eixo microbiota- intestino-cérebro em doenças não relacionadas diretamente com o sistema gastroentérico. Objetivou-se com essa revisão de literatura integrativa categorizar as intervenções propiciadas por esse eixo e suas alterações no hospedeiro. Na análise de 20 artigos científicos entre 2016 e 2019 constatou-se que a presença de um microbioma variável constitui fator de proteção contra o desenvolvimento de doenças como ansiedade e depressão. A disbiose intestinal também foi associada positivamente com doenças neurodegenerativas como Parkinson e Alzheimer. Dessa forma, a compreensão do eixo bidirecional microbiota-intestino-cérebro é fundamental para a elaboração de terapias microbióticas como alternativas para o tratamento das doenças relacionadas.

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Publicado
2019-07-01